S100B Inhibition Reduces Behavioral and Pathologic Changes in Experimental Traumatic Brain Injury
نویسندگان
چکیده
منابع مشابه
Evelotion The Cognitive and behavioral inhibition Of Patients With traumatic brain injury
Aim(s): Inhibition, which is defined as one's ability to monitor and control responses, is one of the most important executive actions that occur after a traumatic brain injury. The purpose of this study was to compare the cognitive and behavioral inhibition in MTBI patients one year after their injury with healthy individuals. Participants & Methods: In this causal-comparative study, which wa...
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Objective(s):Melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.Secondary injury following the primary traumatic brain injury (TBI) results in glial cells activation, especially astrocytes. In fact, astrocyte activation causes the production of pro-inflammatory cytokines...
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Overpressurization blast (OB) exposure used to induce traumatic brain injury (TBI) in the rodent model can result in somatomotor and behavioral changes. Increased anxiety is evidenced after OB TBI in Dorsal and Frontal blast-wave exposed injured animals. Sustained impaired somatosensory functions occur after multiple OB injuries in Dorsal animals. Somatomotor function is impaired acutely but pa...
متن کاملKinetic modelling of serum S100b after traumatic brain injury
BACKGROUND An understanding of the kinetics of a biomarker is essential to its interpretation. Despite this, little kinetic modelling of blood biomarkers can be found in the literature. S100b is an astrocyte related marker of brain injury used primarily in traumatic brain injury (TBI). Serum levels are expected to be the net result of a multi-compartmental process. The optimal sample times for ...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2015
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2015.165